World Agrochemical Network Chinese: From 2021 to August this year, Brazil approved nine new pesticide active ingredients, seven of which are fungicides and the remaining two are insecticides. Among the fungicides, three are SDHI class fungicides.

1. Fluorochloropyridyl ester – Cordyhua

Fluorochloropyralid (halauxifen-methyl) is the first product of a new chemical type of aryl-pyridic acid in synthetic growth herbicides developed by Dow AgroSciences (now Cordova). It is mainly used in wheat, barley, oats, rye, black wheat, soybeans, and Brassica spp. to control a variety of broadleaf weeds such as Artemisia spp., Capsella spp. and pigweed, as well as malignant and resistant weeds.

Previously, flumioxazin has been registered in China, Canada, Australia, Argentina, EU and other countries and regions.

Codewa has registered a combination of fluroxypyr and diclosulam in Brazil. It is used for the control of weeds such as small fleabane (Conyza bonariensis) and two-ear grass (Digitaria insularis) in soybean crops.

2. Cyclanilide – Ishihara, Japan

Cyclaniliprole is an o-formylaminobenzamide insecticide developed by Ishihara in Japan. Like chlorfenvinphos, cyclaniliprole is a diamide, but it does not act on the ichthyonidine receptor, but on the ichthyonidine receptor variant.

Cyclobromanilide has broad-spectrum control activity against a wide range of pests and is highly effective against major lepidopteran pests, and can be used on apples, pears, peaches, apricots, nectarines, plums, grapes, potatoes, greenhouse tomatoes, peppers, and eggplants.

Previously, cyclobreximide has been registered in Japan, Korea, Vietnam, Australia, Canada, Chile, Colombia, Guatemala, Honduras, Mexico, Mexico, and the United States.

In 2021, a single agent of cyclo-bromoxynil registered in Brazil by Ishihara Japan was approved for the control of coffee leafminer, corn, soybean, and tomato crops, including coffee leafminer, weedbug, cotton bollworm, tomato fruit moth (Neoleucinodes elegantalis), and tomato leafminer.

3. fluorothiazole pyrethrone – Cordova

Fluthiapiprolin is the first piperidine-based thiazole isoxaflutole (FRAC 49) fungicide. It has excellent efficacy against oomycete diseases and is effective against downy mildew and late blight.

Fluorothiazole pyriprolin has been registered in the United States, Canada, Australia, New Zealand, the European Union, China and many other countries around the world.

In Brazil, KODIWA has registered fluothiazolepyrione in combination with allylmethoprene, oxazoxystrobin and bispyribuzin, respectively. It is used for the control of late blight and downy mildew, etc.

4. azoxystrobin – BASF

Azoxystrobin (ametoctradin) is a highly selective fungicide that acts as a triazolopyrimidine fungicide and is a mitochondrial respiration inhibitor for the control of oomycete diseases, especially downy mildew and blast fungus.

Azoxystrobin has been registered in dozens of countries/regions worldwide, including the US, EU, India and China.

In 2022, BASF registered azoxystrobin in Brazil in combination with allylmorph and daidzein, respectively, for the control of late blight of potatoes and downy mildew in onions, cucumbers and ornamentals, among others.

5. isofenthiuron – Ishihara, Japan

Isofetamid is a SDHI (succinate dehydrogenase inhibitor) fungicide developed by Ishihara Industries, Japan. The Fungicide Resistance Action Committee (FRAC) classifies isofetamid as Class 7, which has a different mechanism of action from benzimidazoles, triazoles and methoxyacrylates, and has no cross-resistance with common fungicides.

It can effectively control fungal diseases of Cysticerca and Hemiptera, and has excellent efficacy against gray mold of cucumber, tomato, strawberry and powdery mildew of cucumber and other crops.

In July 2021, isopropylthiocarb 95% prod and 400g/L suspension were registered in Brazil and in December in China, where the product is marketed by Ishihara Shanghai and Zhejiang Ishihara Jinniu Chemical Co. In addition, isopropylthiocarb was registered in Canada, USA, EU, Japan, Korea, Australia, New Zealand and other countries and regions.

The patent for isoprothiuron’s compounds in China, Europe and the US will expire on August 9, 2025.

6. inpyrfluxam – Sumitomo Chemical

Inpyrfluxam is a pyrazole amide fungicide developed by Sumitomo Chemical, a succinate dehydrogenase inhibitor with a broad spectrum of action to control major pathogens in crops such as apple, corn, peanut, rice, soybean and sugar beet, both as a foliar spray and as a soil or seed treatment.

In early 2020, inpyrfluxam (trade name: INDIFLIN®) received its first global registration in Japan, followed by approvals in several countries, including the United States, Canada and Argentina. Bayer also registered inpyrfluxam in the same period. Bayer also registered Fox Supra, a combination of inpyrfluxam and prothioconazole, for the control of Asian soybean rust during the same period. 7.

7. butamorpholin – BASF

Butylmorph (fenpropimorph) is a broad-spectrum, systemic morpholine fungicide and ergosterol biosynthesis inhibitor with preventive and therapeutic effects, mainly against barley and wheat powdery mildew, leaf rust, stripe rust and cereal black crop disease, as well as cotton standing blight.

BASF has launched butylmorpholin 750g/L EC for resistance management of Asian rust in soybean back in 2017. However, the original drug registration approval was granted in 2021.

ICAMA has approved a total of five product registrations for butamiphos-methyl, all exclusively for export, to Paraguay and Panama.

8. chlorfluazurone-BASF

Clothianidin is a triazole fungicide developed by BASF, which also belongs to the sterol demethyl inhibitor class of fungicides. It is suitable for more than 60 crops worldwide, including field crops, cash crops and specialty crops, and can prevent and control many fungal diseases that are difficult to control, such as rust and diseases caused by crustaceans.

Clothianidin was first marketed in Korea in 2018 and subsequently received registrations in the U.S., Australia, New Zealand, Canada and many other countries around the world.

BASF has registered one chlorfluazuron prodrug and six formulations in China, four of which are registered as blends with pyraclofosfom, and in 2020, BASF marketed a blend of the two fungicidal ingredients in China to form Rejuveno®.

In January 2022, chlorfluazuron was registered for the first time in Brazil, and the two formulations registered in March were registered as blends with two other fungicides for control of Columnaris, coffee rust, soybean rust and other diseases.

9. flutriafol-hydroxam – Syngenta

Fluaziflumetofen is a new pyrazolamide fungicide developed by Syngenta that acts on succinate dehydrogenase and is used on cereals, corn, soybeans, vegetables, peanuts, rape, quinoa, melons, dry peas and beans, fruit trees, specialty crops, lawns, ornamentals, etc. to control diseases caused by Fusarium spp. Cercospora spp.), Staphylococcus spp. (Botrytis spp.), Streptococcus spp. (Alternaria spp.) and other pathogens, mainly through foliar sprays, but also for seed treatment.

In 2016, flutriafol hydroxamate received its first registration in Argentina. Fluazifop-methyl hydroxamate is now registered in more than 50 countries worldwide for use on more than 100 crops and against more than 30 major diseases. Its markets cover Argentina, Uruguay, New Zealand, Chile, USA, Canada, Korea, Australia, Guatemala, Zambia, China, Japan, etc.

In 2022, flumioxazin-hydroxam was approved for registration in Brazil for both the original and formulation, and four of the five compounding registrations were for compounding with tebuconazole.